The association between serum thyroid-stimulating hormone concentration and development of differentiated thyroid cancers in nodular thyroid disease

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Abstract

Objective
To evaluate the relation between serum thyroid-stimulating hormone (TSH) and development of differentiated thyroid cancers in nodular thyroid disease (NTD) in Egyptians.
Patients and methods
One hundred patients were included in this study at Al-Azhar University Hospitals from 2010 to 2013; all patients with NTD, who were fit for surgery, were selected for study. The preoperative TSH level was estimated and was compared with the final histopathological diagnosis for the presence of malignant thyroid lesions.
Results
A total of 100 patients were included in the study, with an average age of 46 years. The male to female ratio was 1 : 4.7. Seventy-five patients had multinodular goiter, whereas 25 patients had a solitary thyroid nodule. Eighty-six patients underwent total thyroidectomy, whereas 14 patients underwent near- total thyroidectomy. The final histopathological data showed no evidence of malignancy in 83 patients, 83% (benign group), whereas malignant lesions were present in 17 patients, 17% (malignant group). The preoperative mean TSH level in the benign group was 1.72 ± 1.4 mIU/L, whereas the mean TSH concentration in the malignant group was 2.61 ± 2.2 mIU/l.
Conclusion
There is a definite relation between serum TSH and development of differentiated thyroid cancers in NTD as the risk of thyroid malignancy increases with increased serum TSH concentrations.

Keywords

Journal of the Arab Society for Medical Research
Volume 9, Issue 1
January 2014
Pages 28-32

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