Inhibitory effect of bee venom against potassium bromate causing genetic toxicity and biochemical alterations in mice

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Abstract

Background/aim
Bee venom (BV) therapy is a highly effective treatment, capable of improving one’s health. The present study attempts to assess the effect of BV on the toxicity of oral administration of potassium bromate (KBrO) which has been widely used in food and cosmetic industries.
Materials and methods
Sixty adult male mice were gavaged with KBrO at two doses (100 and 200 mg/kg body weight) for 10 days. Afterwards, BV at a dose of 120 μg/kg body weight was injected subcutaneously three times per week for two successive weeks. The genetic study was performed using chromosomal aberration and micronucleus formation in the bone marrow, DNA fragmentation in liver cells and by sperm analysis. In addition, serum biochemical markers such as catalase and malondialdehyde, kidney, and liver functions were assessed.
Results
The results have shown that KBrO caused DNA damage that represented the increase in the frequencies of chromosome abnormalities, micronuclei formation, percentage of DNA fragmentation, and sperm morphological abnormalities. Meanwhile, the results showed that KBrO exhibited severe toxicity for antioxidant activities for liver and kidney functions. Conversely, BV significantly decreased the frequencies of DNA damage in all aforementioned parameters induced by KBrO. In addition, it improved the antioxidant activities and the function of the liver and kidneys.
Conclusion
BV has a potent ameliorating effect against the KBrO hazard impacts in animal tissues especially at higher doses. This observation indicated that BV could be a potential therapeutic agent in the treatment of KBrO risk.

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Journal of the Arab Society for Medical Research
Volume 13, Issue 2
July 2018
Pages 89-98

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